I've been running Windows 10 on one machine just fine with my M2PC. I just tried updating my main show PC and the internal touchscreen went all glitchy and unusable.
After the Win10 install, I completely removed Martin MPC, Martin Drivers, and used the cleanup script. I plugged my M2PC into my other PC and the screen was working fine. I reverted back to Win8 and the M2PC is fine.